{"id":3480,"date":"2025-08-13T09:56:37","date_gmt":"2025-08-13T15:56:37","guid":{"rendered":"https:\/\/immunotherapynk.com\/?p=3480"},"modified":"2025-08-13T10:28:19","modified_gmt":"2025-08-13T16:28:19","slug":"el-caseinato-de-sodio-una-estrategia-innovadora-contra-la-resistencia-a-la-quimioterapia-en-la-leucemia-mieloide-aguda","status":"publish","type":"post","link":"https:\/\/immunotherapynk.com\/es\/el-caseinato-de-sodio-una-estrategia-innovadora-contra-la-resistencia-a-la-quimioterapia-en-la-leucemia-mieloide-aguda\/","title":{"rendered":"Caseinato de sodio: Una estrategia innovadora contra la resistencia a la quimioterapia en la leucemia mieloide aguda"},"content":{"rendered":"<p>En <strong>leucemia mieloide aguda (LMA)<\/strong>uno de los retos cl\u00ednicos m\u00e1s persistentes es <strong>quimiorresistencia<\/strong>en particular a <strong>citarabina (Ara-C)<\/strong> - un f\u00e1rmaco fundamental en los protocolos de tratamiento de la LMA. Cuando se desarrolla resistencia, la eficacia de los reg\u00edmenes est\u00e1ndar disminuye dr\u00e1sticamente, lo que limita las opciones terap\u00e9uticas y compromete los resultados de los pacientes.<\/p>\n\n\n\n<p>Un reciente estudio revisado por pares en el <em>Revista Internacional de Ciencias Moleculares<\/em> destaca el potencial de <strong>caseinato s\u00f3dico<\/strong>una sal proteica derivada de la leche, como un <strong>enfoque terap\u00e9utico adyuvante<\/strong> para mejorar la eficacia de la quimioterapia convencional en <strong>LMA farmacorresistente<\/strong>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mecanismo de acci\u00f3n<\/h2>\n\n\n\n<p>Cuando se administr\u00f3 solo o en combinaci\u00f3n con citarabina o daunorrubicina, se demostr\u00f3 que el caseinato de sodio:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Suprimir la proliferaci\u00f3n<\/strong> de c\u00e9lulas de LMA resistentes a los f\u00e1rmacos.<\/li>\n\n\n\n<li><strong>Potenciar la apoptosis<\/strong> (muerte celular programada) m\u00e1s eficazmente que las monoterapias.<\/li>\n\n\n\n<li><strong>Modular los genes relacionados con la resistencia<\/strong>Regulaci\u00f3n a la baja <strong>SIRT1<\/strong> y <strong>MDR1<\/strong>mientras que la regulaci\u00f3n <strong>ENT1<\/strong> y <strong>dCK<\/strong> - mol\u00e9culas clave para el transporte y la activaci\u00f3n de la citarabina.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Principales resultados<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Supervivencia prolongada<\/strong> en modelos animales: hasta <strong>50 d\u00edas<\/strong> en casos de LMA resistente frente a <strong>40 d\u00edas<\/strong> con quimioterapia sola.<\/li>\n\n\n\n<li><strong>Actividad sin\u00e9rgica<\/strong>: las combinaciones de dosis bajas (IC25) lograron el mismo efecto inhibidor que las dosis m\u00e1s altas, creando una oportunidad para reducir la toxicidad relacionada con la quimioterapia.<\/li>\n\n\n\n<li><strong>Citotoxicidad selectiva<\/strong>: se dirigi\u00f3 a las c\u00e9lulas malignas sin perjudicar a los progenitores sanos de la m\u00e9dula \u00f3sea.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Importancia cl\u00ednica<\/h2>\n\n\n\n<p>Estos hallazgos sugieren que el caseinato de sodio podr\u00eda servir como un <strong>coadyuvante prometedor en el tratamiento de la LMA<\/strong>especialmente en pacientes con una respuesta limitada a los reg\u00edmenes basados en citarabinas. Al restaurar potencialmente la sensibilidad a los f\u00e1rmacos, esta estrategia puede mejorar <strong>eficacia del tratamiento<\/strong>reducir <strong>necesidades de dosis de quimioterapia<\/strong>y contribuir a <strong>mejor calidad de vida<\/strong>.<\/p>\n\n\n\n<p>Esta investigaci\u00f3n a\u00f1ade un nuevo candidato al creciente campo de la <strong>terapias combinadas de precisi\u00f3n<\/strong> destinados a superar los mecanismos de resistencia en las neoplasias hematol\u00f3gicas.<\/p>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>In acute myeloid leukemia (AML), one of the most persistent clinical challenges is chemoresistance, particularly to cytarabine (Ara-C) \u2014 a [&hellip;]<\/p>","protected":false},"author":1,"featured_media":3500,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_joinchat":[],"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3480","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer"],"_links":{"self":[{"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/posts\/3480","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/comments?post=3480"}],"version-history":[{"count":0,"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/posts\/3480\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/media\/3500"}],"wp:attachment":[{"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/media?parent=3480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/categories?post=3480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/immunotherapynk.com\/es\/wp-json\/wp\/v2\/tags?post=3480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}